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docetaxel/vitamin E TPGS-loaded poly(lactic-co-glycolic acid) nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

PLGA/TPGS mixture

Type Complex Compound
Formula
Role raw materials
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
differential scanning calorimetry

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Biological effects

Biological system Test details Nanomaterial Variant Source
HeLa cell line

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Preparation

Method 1

Type: Physical formation
Source:
Product

docetaxel/vitamin E TPGS-loaded poly(lactic-co-glycolic acid) nanoparticles

Size: ~ 96.44 - 108.68 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic-co-glycolic acid)
  • d-α-tocopheryl polyethylene glycol 1000 succinate
  1. 9mWfz13vKq3Fq2O78Q
Product

docetaxel/vitamin E TPGS-loaded poly(lactic-co-glycolic acid) nanoparticles

Size: 96.44 - 108.68 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Product

docetaxel/vitamin E TPGS-loaded poly(lactic-co-glycolic acid) nanoparticles

Size: ~ 112.9 - 120.7 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic-co-glycolic acid)
  • d-α-tocopheryl polyethylene glycol 1000 succinate
  1. TJ4q0soaldEOi8oXXr
Product

docetaxel/vitamin E TPGS-loaded poly(lactic-co-glycolic acid) nanoparticles

Size: 112.9 - 120.7 nm

Medium: water

Support: none

References

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