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docetaxel-loaded hyaluronic acid-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules

Based on

1 Articles
2014 Most recent source

Composition

1

Labrafac® CC

Type Complex Compound
Formula
Role core
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material
3

hyaluronic acid-conjugated polyethylene glycol/poly(ε-caprolactone)

HA-PEG/PCL
Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human breast carcinoma MDA-MB 231 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • hyaluronic acid-conjugated polyethylene glycol/poly(ε-caprolactone)
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • Labrafac® CC
  1. jAj1ltfD7yWIcygnhPwftIw488Pk
  2. tzAA4zJO3jf
Product

docetaxel-loaded hyaluronic acid-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules

Hydrodynamic diameter: ~ 522.1 nm

Medium: aqueous trehalose solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • hyaluronic acid-conjugated polyethylene glycol/poly(ε-caprolactone)
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • Labrafac® CC
  1. TT2PJZ6AlYeZFPLRc9WaimDMLdrO
  2. KWKtfFCHeyV
Product

docetaxel-loaded hyaluronic acid-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules

Hydrodynamic diameter: ~ 222.6 nm

Medium: aqueous trehalose solution

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • hyaluronic acid-conjugated polyethylene glycol/poly(ε-caprolactone)
  • Labrafac® CC
  1. KDGRS76klUJgwTbiLAaaHPMWmljT
  2. qivzy0jmjLW
Product

docetaxel-loaded hyaluronic acid-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules

Hydrodynamic diameter: ~ 474.9 nm

Medium: aqueous trehalose solution

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • hyaluronic acid-conjugated polyethylene glycol/poly(ε-caprolactone)
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • Labrafac® CC
  1. yEaX4LNnVKu7w1gNdJL8bm7oRCjw
  2. 750n6cf8gi8
Product

docetaxel-loaded hyaluronic acid-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules

Hydrodynamic diameter: ~ 220.2 nm

Medium: aqueous trehalose solution

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • hyaluronic acid-conjugated polyethylene glycol/poly(ε-caprolactone)
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • Labrafac® CC
  1. CBX1fCnxDkA47ls1QOqqSCphrrrN
  2. f6Uyhakt1sG
Product

docetaxel-loaded hyaluronic acid-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules

Hydrodynamic diameter: ~ 268.9 nm

Medium: aqueous trehalose solution

Support: none

References

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