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docetaxel-loaded hyaluronic acid-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules

Based on

1 Articles
2014 Most recent source

Composition

1

Labrafac® CC

Type Complex Compound
Formula
Role core
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Dtx Doc
Type Single Compound
Formula C43H53NO14
Role loaded material
3

hyaluronic acid-conjugated polyethylene glycol/poly(ε-caprolactone)

HA-PEG/PCL
Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human breast carcinoma MDA-MB 231 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • hyaluronic acid-conjugated polyethylene glycol/poly(ε-caprolactone)
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • Labrafac® CC
  1. UCdHP9QzVD4VOyHA3GXReJyaEAxW
  2. wWP52kaWgmJ
Product

docetaxel-loaded hyaluronic acid-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules

Hydrodynamic diameter: ~ 234.2 nm

Medium: aqueous trehalose solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • hyaluronic acid-conjugated polyethylene glycol/poly(ε-caprolactone)
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • Labrafac® CC
  1. BQfkXTEfdGFZ0XUyt5uxqPCrZycs
  2. QjQcZgd0NOJ
Product

docetaxel-loaded hyaluronic acid-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules

Hydrodynamic diameter: ~ 468.8 nm

Medium: aqueous trehalose solution

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • hyaluronic acid-conjugated polyethylene glycol/poly(ε-caprolactone)
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • Labrafac® CC
  1. 47XexndIId7BbbowNHcn9cRzWbE3
  2. W0wUUMsZhvI
Product

docetaxel-loaded hyaluronic acid-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules

Hydrodynamic diameter: ~ 451.5 nm

Medium: aqueous trehalose solution

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • hyaluronic acid-conjugated polyethylene glycol/poly(ε-caprolactone)
  • Labrafac® CC
  1. hPmmWjTbGPKlsZzN9jAs4a4MTLJk
  2. jRQTe1Ct0Uu
Product

docetaxel-loaded hyaluronic acid-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules

Hydrodynamic diameter: ~ 225.9 nm

Medium: aqueous trehalose solution

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • hyaluronic acid-conjugated polyethylene glycol/poly(ε-caprolactone)
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • Labrafac® CC
  1. jPAmk6lyC8J3Hw8kPYB2Etynwfrj
  2. Oth6sruLxvz
Product

docetaxel-loaded hyaluronic acid-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules

Hydrodynamic diameter: ~ 111.6 nm

Medium: aqueous trehalose solution

Support: none

References

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