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bortezomib-loaded Ald-PEG-PLGA NP

Based on

1 Articles
2014 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

Ald-PEG-PLGA NP

Ald-PP NP
Type Nano Material
Formula
Role carriers
2

pyrazylcarbonyl-Phe-Leuboronate

bortezomib Bortezomib Velcade PS-341 BTZ
Type Single Compound
Formula C19H25BN4O4
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
biomimetic calcium phosphate binding

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
BALB/c bearing human multiple myeloma MM1S cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • PLGA-b-PEG
  • pyrazylcarbonyl-Phe-Leuboronate
  • alendronate-conjugated polymer
  1. 4tZn
  2. qh3ZyVg9fx
  3. 5TMjnG
Product

bortezomib-loaded Ald-PEG-PLGA NP

Hydrodynamic diameter: ~ 192 nm

Medium: Hepes buffer

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • PLGA-b-PEG
  • pyrazylcarbonyl-Phe-Leuboronate
  • alendronate-conjugated polymer
  1. hbFD
  2. XlCq6fcvgY
  3. AzE38D
Product

bortezomib-loaded Ald-PEG-PLGA NP

Hydrodynamic diameter: ~ 218 nm

Medium: Hepes buffer

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • PLGA-b-PEG
  • pyrazylcarbonyl-Phe-Leuboronate
  • alendronate-conjugated polymer
  1. IHfA
  2. NHqOkc1KkxEn
  3. N5HEC9
Product

bortezomib-loaded Ald-PEG-PLGA NP

Hydrodynamic diameter: ~ 80 nm

Medium: Hepes buffer

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • PLGA-b-PEG
  • pyrazylcarbonyl-Phe-Leuboronate
  • alendronate-conjugated polymer
  1. dq9j
  2. USZcoqwQ2DL5
  3. fKV5cx
Product

bortezomib-loaded Ald-PEG-PLGA NP

Hydrodynamic diameter: ~ 100 nm

Medium: Hepes buffer

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • PLGA-b-PEG
  • pyrazylcarbonyl-Phe-Leuboronate
  • alendronate-conjugated polymer
  1. Cag5
  2. L8sargpvU1
  3. a07kPs
Product

bortezomib-loaded Ald-PEG-PLGA NP

Hydrodynamic diameter: ~ 195 nm

Medium: Hepes buffer

Support: none

References

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