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HPMC/DOSS-coated megestrol nanoparticles dispersion

Based on

3 Patents
2015 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

megestrol acetate

Type Single Compound
Formula C24H32O4
Role core
2

hydroxypropyl methylcellulose

HPMC
Type Biomolecule
Formula
Role layer
3

sodium 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate

sodium 1,4-bis(2-ethylhexyl)sulfosuccinate sodium bis(2-ethylhexyl)-sulfosuccinate sodium bis(2-ethylhexyl)sulfosuccinate dioctyl sulfosuccinate sodium salt dioctyl sodium sulfosuccinate Docusate sodium docusate sodium sodium docusate Aerosol OT aerosol OT NaAOT DOSS AOT
Type Single Compound
Formula C20H37NaO7S
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
physical stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
laser diffraction spectroscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
fasted male beagle dog

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Preparation

Method 1

Type: Physical formation
Source:
Product

HPMC/DOSS-coated megestrol nanoparticles dispersion

Diameter: 173 nm

Medium: citric acid monohydrate/glycerol/lemon flavor/sodium benzoate/sodium citrate dihydrate/xanthan gum water solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • hydroxypropyl methylcellulose
  • sodium benzoate
  • water
See all (7)
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  2. WOoDQlifoFnnOSZBjAg1qLRswM3
  3. rBYex1
Product

HPMC/DOSS-coated megestrol nanoparticles dispersion

Size: 146 nm

Medium: sodium benzoate/sodium citrate dihydrate/citric acid monohydrate water solution

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • saccharose
  • artificial lime flavor
  • natural and artificial lemon flavor
See all (5)
Product

HPMC/DOSS-coated megestrol nanoparticles dispersion

Size: 145 - 169 nm

Medium: sodium benzoate/sodium citrate dihydrate/citric acid monohydrate water solution

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • hydroxypropyl methylcellulose
  • sodium benzoate
  • water
See all (6)
  1. Jb0pODck4zTxaeBTtKK
  2. aMT35QdCkc6dDvljVMPQsJzjyJj
  3. sIgPkm
Product

HPMC/DOSS-coated megestrol nanoparticles dispersion

Size: not specified

Medium: sodium benzoate/citric acid monohydrate water solution

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • saccharose
  • artificial lime flavor
  • natural and artificial lemon flavor
See all (5)
Product

HPMC/DOSS-coated megestrol nanoparticles dispersion

Size: 144 - 169 nm

Medium: sodium benzoate/sodium citrate dihydrate/citric acid monohydrate water solution

Support: none

References

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