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poly(vinyl acetate-co-vinyl pyrrolidone)/dioctyl sodium sulfosuccinate-coated megestrol acetate nanoparticles

Based on

3 Patents
2015 Most recent source

Composition

1

megestrol acetate

Type Single Compound
Formula C24H32O4
Role core
2

poly(vinyl acetate-co-vinyl pyrrolidone)

Plasdone® S630
Type Polymer
Formula
Role layer
3

sodium 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate

sodium 1,4-bis(2-ethylhexyl)sulfosuccinate sodium bis(2-ethylhexyl)-sulfosuccinate sodium bis(2-ethylhexyl)sulfosuccinate dioctyl sulfosuccinate sodium salt dioctyl sodium sulfosuccinate Docusate sodium docusate sodium sodium docusate Aerosol OT aerosol OT NaAOT DOSS AOT
Type Single Compound
Formula C20H37NaO7S
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
physical stability dependent on temperature

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
laser diffraction spectroscopy

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(vinyl acetate-co-vinyl pyrrolidone)
  • sodium 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate
  • megestrol acetate
  1. OdIoVZMEft7S9JoB6iB
Product

poly(vinyl acetate-co-vinyl pyrrolidone)/dioctyl sodium sulfosuccinate-coated megestrol acetate nanoparticles

Size: 167 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(vinyl acetate-co-vinyl pyrrolidone)
  • sodium 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate
  • megestrol acetate
  1. xbP4TRSSeJpaZOdYHoQ
Product

poly(vinyl acetate-co-vinyl pyrrolidone)/dioctyl sodium sulfosuccinate-coated megestrol acetate nanoparticles

Size: 167 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(vinyl acetate-co-vinyl pyrrolidone)
  • sodium 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate
  • megestrol acetate
  1. v8a9Tg2SXPA5cS2yPDV
Product

poly(vinyl acetate-co-vinyl pyrrolidone)/dioctyl sodium sulfosuccinate-coated megestrol acetate nanoparticles

Size: 167 nm

Medium/Support: none

References

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