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doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Based on

4 Articles
2016 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

poly(ethylene glycol)-poly(D,L-lactide) block copolymer

PEG5-PLA5 copolymer PEG5-PLA5
Type Polymer
Formula
Role raw materials
2

doxorubicin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
cancer stem cell-enriched MDA-MB-231 mammosphere cell line

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • polyethylene glycol-block-poly(D,L-lactide)
  • doxorubicin
  1. e35N
  2. tvAl5PhlKaaGc4m22u7L
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Diameter: 68 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • doxorubicin
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. gCJh5L5eIbeqFzN2IU6KHuUjHsQ
  2. Tk5JE
  3. k319VF7gXm8u6eB
  4. 24QsrJM
  5. LQriifEjD9VUK0yePZLYpbYXpIbH1Q4MA
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Hydrodynamic diameter: 114.9 - 121.7 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Hydrodynamic diameter: 134.95 - 139.27 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • doxorubicin
  • poly(ethylene glycol)-poly(D,L-lactide) block copolymer
  • water
  1. n7O
  2. pmVpzyyt
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Size: 36.0 - 52.2 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • doxorubicin
  • poly(ethylene glycol)-poly(D,L-lactide) block copolymer
  • water
  1. Qxs
  2. xwVrQuMz
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Size: 36.93 - 48.27 nm

Medium: water

Support: none

References

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