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doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Based on

8 Articles
2016 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

mPEG-PCL

Type Polymer
Formula
Role raw materials
2

doxorubicin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
BALB/c mouse with breast cancer 4T1 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • doxorubicin
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. yijDaJj57xXFkiRdQJWkWrulrg1
  2. n25eC
  3. eANGMSJaowccaoD
  4. lqmHP9P
  5. JAyw0ORe1x079srRIfRtb9GHnYgyb9rwc
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Hydrodynamic diameter: 114.9 - 121.7 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • polyethylene glycol-block-poly(D,L-lactide)
  • doxorubicin
  1. tuWw
  2. qvPhBkBk2lLlfiWqDI6U
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Diameter: 68 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • polyethylene glycol-block-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane)
  • doxorubicin
  1. jiog
  2. LxKGWmGigu1ERrAMjuzg
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Diameter: 68 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • doxorubicin
  • poly(ethylene glycol)-poly(D,L-lactide) block copolymer
  • water
  1. lEZ
  2. U583kmBy
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Size: 42.73 - 49.67 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • doxorubicin
  • poly(ethylene glycol)-poly(D,L-lactide) block copolymer
  • water
  1. 2ut
  2. 27xoUdTn
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Size: 45.47 - 58.13 nm

Z-average size: ~ 50 nm

Medium: water

Support: none

References

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