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prostate-specific membrane antigen-targeted cisplatin/irinotecan-loaded nanoparticles

Based on

1 Patents
2014 Most recent source

Composition

1

PLGA-mPEG5K

Type Polymer
Formula
Role core
2

poly(lactide-co-glycolic acid)-polyethyleneglycol-S,S-2[3-][5-amino-1-carboxypentyl]-ureido]-pentanedioic acid

PLGA-mPEG5K-LIG
Type Polymer
Formula
Role layer
3

PLA-succinic acid-conjugated cisplatin

polylactic acid-cisplatin PLA-cisplatin
Type Polymer
Formula
Role loaded material
4

(S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate

irinotecan Camptosa CPT
Type Single Compound
Formula C33H38N4O6
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability dependent on solvents

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human prostatic carcinoma PSMA-overexpressing LNCaP cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated cisplatin
  • (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate
  • PLGA-mPEG5K
See all (4)
  1. Qb9AujVSfA4vVdHktGwUgD5iPWF
Product

prostate-specific membrane antigen-targeted cisplatin/irinotecan-loaded nanoparticles

Diameter: 40 - 80 nm

Medium/Support: none

References

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