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doxorubicin-loaded poly(2-hydroxyethyl methacrylate)-g-(poly(ε-caprolactone)-adenine:uracil-poly(ethylene glycol)) micelles

Based on

1 Articles
2012 Most recent source

Composition

1

doxorubicin hydrogen chloride

adriblastin hydrochloride doxorubicin hydrochloride adriamycin hydrochloride doxorubicin hydrochoride adriblastin HCl salt adriamycin HCl salt DOX hydrochloride DXR hydrochloride doxorubicin HCl DOX*HCl DOX-HCl DOX·HCl DXR HCl DXR*HCl Dox HCl Dox*HCl DOXS
Type Single Compound
Formula C27H29NO11*HCl
Role core
2

poly(2-hydroxyethyl methacrylate)-g-(poly(ε-caprolactone)-adenine)

PHEMA-g-(PCL-A)
Type Polymer
Formula
Role layer
3

uracil-terminated poly(ethylene glycol)

PEG-U
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
HeLa (human uterine cervix carcinoma) cell

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • doxorubicin hydrogen chloride
  • poly(2-hydroxyethyl methacrylate)-g-(poly(ε-caprolactone)-adenine)
  • uracil-terminated poly(ethylene glycol)
  1. d7ISKvfmE3bTMH9svI0Kbjwj5TiocXqa
  2. zEjxW0ToDvSpI8scZ5R6Oiay3Rc9wNFjLDkyxfhI7gjsT1unYmiJh177Rnq
  3. j7j60vvbbWgInKMMqOnQEXkbDU2fnVrWw3bSer5HiU
Product

doxorubicin-loaded poly(2-hydroxyethyl methacrylate)-g-(poly(ε-caprolactone)-adenine:uracil-poly(ethylene glycol)) micelles

Diameter: ~ 50 nm

Hydrodynamic diameter: ~ 96 nm

Medium/Support: none

References

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