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itraconazole-loaded PLGA nanoparticles

Based on

1 Articles
2013 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

poloxamer 188

poloxamer 188
Type Polymer
Formula
Role layer
3

cis-2-sec-butyl-4-[4-(4-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4- ylmethoxy]phenyl}piperazin-1-yl)phenyl]-2,4-dihydro-1,2,4-triazol-3-one

itraconazole
Type Single Compound
Formula C35H38Cl2N8O4
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
Sprague Dawley rats

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(lactic-co-glycolic acid)
  • cis-2-sec-butyl-4-[4-(4-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4- ylmethoxy]phenyl}piperazin-1-yl)phenyl]-2,4-dihydro-1,2,4-triazol-3-one
  1. 2ZAI487WpileF0QYpAEvsBBPRi52bVhQlUXhmNMz4eYDZsTvfBC5KNYf7sSO7cPZfso
Product

itraconazole-loaded PLGA nanoparticles

Hydrodynamic diameter: 189 - 193 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
  1. G8OrDO3lKaPFsfXZ
  2. X5c6tPWiyE2rbDeYc
  3. xnWN
Product

itraconazole-loaded PLGA nanoparticles

Hydrodynamic diameter: 271 - 283 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(lactic-co-glycolic acid)
  • cis-2-sec-butyl-4-[4-(4-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4- ylmethoxy]phenyl}piperazin-1-yl)phenyl]-2,4-dihydro-1,2,4-triazol-3-one
  1. YJieUbfVhNy7OhFBek6jVAUW0T8B7XzzOo3BbLukUQPGNMxEv9TIkysRw9eYTjSM77
Product

itraconazole-loaded PLGA nanoparticles

Hydrodynamic diameter: 170 - 180 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
  1. c7KVQNbD0Yyk74P
  2. FGFsaF3mN7JOrfMZV
  3. 7Nzl
Product

itraconazole-loaded PLGA nanoparticles

Hydrodynamic diameter: 192 - 198 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
  1. hEB8hWTDRsJQufI
  2. zrcV6azlvBcsesMyU
  3. xxet
Product

itraconazole-loaded PLGA nanoparticles

Hydrodynamic diameter: 204 - 216 nm

Medium: water

Support: none

References

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