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oil-filled lipid nanoparticles containing docetaxel conjugate

Based on

1 Articles
2011 Most recent source

Composition

1

propane-1,2,3-triyl trioctanoate

1,2,3-trioctanoyl glycerol caprylic acid triglyceride caprylic triglyceride glyceryl tricaprylate Miglyol® 808 Captex® 8000 Captex 8000 trioctanoin miglyol 808 tricaprylin
Type Single Compound
Formula C27H50O6
Role core
2

polyoxyl 20-stearyl ether

Brij 78
Type Polymer
Formula
Role layer
3

D-α-tocopheryl polyethylene glycol succinate

vitamin E TPGS TPGS
Type Polymer
Formula
Role layer
4

2'-lauroyl-docetaxel

C12-DX
Type Single Compound
Formula C55H75NO15
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human prostate cancer DU-145 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • propane-1,2,3-triyl trioctanoate
  • polyoxyl 20-stearyl ether
  • D-α-tocopheryl polyethylene glycol succinate
  1. FRz5biF
Product

oil-filled lipid nanoparticles containing docetaxel conjugate

Size: ~ 219.7 nm

Medium: aqueous lactose solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • polyoxyl 20-stearyl ether
  • propane-1,2,3-triyl trioctanoate
  • D-α-tocopheryl polyethylene glycol succinate
  1. cqgztfm
Product

oil-filled lipid nanoparticles containing docetaxel conjugate

Size: not specified

Medium: aqueous lactose solution

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • polyoxyl 20-stearyl ether
  • propane-1,2,3-triyl trioctanoate
  • D-α-tocopheryl polyethylene glycol succinate
  1. bfrv0js
Product

oil-filled lipid nanoparticles containing docetaxel conjugate

Size: ~ 198.2 nm

Medium: aqueous lactose solution

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • polyoxyl 20-stearyl ether
  • propane-1,2,3-triyl trioctanoate
  • D-α-tocopheryl polyethylene glycol succinate
  1. FKTlbLo
Product

oil-filled lipid nanoparticles containing docetaxel conjugate

Size: ~ 204 nm

Medium: aqueous lactose solution

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • propane-1,2,3-triyl trioctanoate
  • polyoxyl 20-stearyl ether
  • D-α-tocopheryl polyethylene glycol succinate
  1. 1V0mCG7
Product

oil-filled lipid nanoparticles containing docetaxel conjugate

Size: ~ 202.4 nm

Medium: aqueous lactose solution

Support: none

References

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