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DTX-loaded Pluronic P105/F127 mixed micelles

Based on

1 Articles
2013 Most recent source

Composition

1

Pluronic P105

Type Polymer
Formula
Role raw materials
2

EO106PO70EO106

Pluronic F127
Type Polymer
Formula
Role raw materials
3

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Dtx Doc
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
differential scanning calorimetry

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Biological effects

Biological system Test details Nanomaterial Variant Source
A549/Taxol cell-bearing BALB/c nude mice

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • Pluronic P105
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • EO106PO70EO106
  1. jUnDQ5AQuMX8
  2. iTxbnCm2qPFka4rqrv
  3. hXxEm07w0SZOq
Product

DTX-loaded Pluronic P105/F127 mixed micelles

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • Pluronic P105
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • EO106PO70EO106
  1. vEwEsYfnnMHe
  2. JgaFSUiVtDTvc4s
  3. g0lX2dV4NBn2j
Product

DTX-loaded Pluronic P105/F127 mixed micelles

Size: not specified

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • Pluronic P105
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • EO106PO70EO106
  1. D1qpmpdQnnFY
  2. xIdPKoUarcu9WvS
  3. zfgD8NhxqQBX9
Product

DTX-loaded Pluronic P105/F127 mixed micelles

Size: not specified

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • Pluronic P105
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • EO106PO70EO106
  1. 4JJhRQt75qhQ
  2. z6qODHpAgjVoNztUXk
  3. PXJu80hT1dNNp
Product

DTX-loaded Pluronic P105/F127 mixed micelles

Size: not specified

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • Pluronic P105
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • EO106PO70EO106
  1. 3IJDino2EEZQ
  2. vfIrBR5jQ6LUbFyc6x
  3. TmpqK1PyyEvUu
Product

DTX-loaded Pluronic P105/F127 mixed micelles

Size: not specified

Medium/Support: none

References

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