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paclitaxel-loaded poly(lactide)-poly(ethylene glycol) nanoparticles

Based on

3 Articles
2013 Most recent source

Composition

1

Paclitaxel

Plaxicel Abraxane Paxene Taxol PCL PAC PTX PX
Type Single Compound
Formula C47H51NO14
Role core
2

poly(lactide)-poly(ethylene glycol)-COOH block copolymer

PLA-PEG-COOH
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human glioblastoma U-87 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • Paclitaxel
  1. qaEzxm4PfKX4GFuddbfJhbiq
Product

paclitaxel-loaded poly(lactide)-poly(ethylene glycol) nanoparticles

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • Paclitaxel
  1. rRYUDRlRPNbBFGJ6iFRgGBR1
Product

paclitaxel-loaded poly(lactide)-poly(ethylene glycol) nanoparticles

Size: not specified

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(glycolide-co-ε-caprolactone)-b-D-α-tocopheryl PEG 2000 succinate diblock copolymer
  • Paclitaxel
  1. VaypOcD1yp2I1JmErubSWtlksHoWUHbeFIZUW
  2. XTARoBFjOcTeu1che
  3. MbtAXgDeig
  4. BtJHS
Product

paclitaxel-loaded poly(lactide)-poly(ethylene glycol) nanoparticles

Diameter: 196.8 - 207.4 nm

Hydrodynamic diameter: ~ 70 - ~ 120 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
  1. rnXwYYEOxjiENq8X
Product

paclitaxel-loaded poly(lactide)-poly(ethylene glycol) nanoparticles

Size: 269.0 - 320.8 nm

Medium: water

Support: none

References

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