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poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Based on

1 Patents
2014 Most recent source

Composition

1

acetylated carboxymethylcellulose

CMC-Ac
Type Biomolecule
Formula
Role raw materials
2

poly(ethylene glycol) methyl ether

mPEG-OH
Type Polymer
Formula
Role graft
3

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
EMT-6 tumor-bearing female BALB/c mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. UjRJWTD0XJw9rqnr1XLoxTPzvzUCE
  2. McVPAoxtWeJsMbdM0sluEPEEes5LTtUpJT1fbEY7XEvRfIFycjVhDsMSF2EBpwA4mEQdXE
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 71.8 nm

Medium: water

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. 4U132zBMl9DpvQ6t6JoUomQKXMNO3
  2. ITbvo7R9aAtXmVWKo73ctIg6KibvvekpZAUCV1MkMAturzpjhQEXo8cnRDG80qE4laZbJs
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 119 nm

Medium: water

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. 98UvPJQ8jeFjsLqxroeXqXKHi4yar
  2. ekII2ozeudUAGvPE4fEkvonf6DoTJaYGsoZ0sqXOz2IY8cE8Jdj1kUlVZBwsSCKwpr38tl
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 107.2 nm

Medium: water

Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. TJwXqID7MZMydfZ8Q65yIezoI2Lda
  2. uW2FVxsMaYr73mOb1XXRVBEZNa34unCxpqXT779x3J1tWB5YFaqzQKRll8cqj9OQThkR6X
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 118.4 nm

Medium: water

Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. yg2EsvBB2F1gmP7RfDfmNVvRwIWqG
  2. gqnFldSkDvonoa8bBQXdKLxEfMlEUcg76CE0F3GeHY2bmtvLqVt6eI4A2umbNLBvDUnfPE
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 49.4 nm

Medium: water

Support: none

References

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