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poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Based on

1 Patents
2014 Most recent source

Composition

1

acetylated carboxymethylcellulose

CMC-Ac
Type Biomolecule
Formula
Role raw materials
2

poly(ethylene glycol) methyl ether

mPEG-OH
Type Polymer
Formula
Role graft
3

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Dtx Doc
Type Single Compound
Formula C43H53NO14
Role loaded material

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
EMT-6 tumor-bearing female BALB/c mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. ML5WfkaBEPqzi5emNkgwkPAINUGg4
  2. 8eWDt0OmxCB71pOiW62zCwsZw9sJOXaU0fjR4iuyAZpz6g7jATA69eC8ERC8vfmyurAjZI
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 117.8 nm

Medium: water

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. 2XzLsc1KXs4N5En7rFRUaDSVCCWJ9
  2. jqcFxwdAwBkmaONqsvKftTibcOYvLef7oLUvxBpcrG7oZMiMDJemOr1ANcKZLv8Wsl7AyQ
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 118.4 nm

Medium: water

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. I3C1CPlZO8a7tEeE3vdLqIqRuhdF3
  2. 2UKqs61KN3WwypiMnNHwX3xKydnO9SPAM3vTQgYcWxnbZqXx2RHw72j7nl9As2UF02bJKo
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 102.1 nm

Medium: water

Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. DwMzZ1taAJts5DeALgEIPyrZNbdBx
  2. IIWJ1AyLOiMo6m6cvRb6yRMfssqdL0bNnHJZ909EI4vgBrz0ElQLmsMdqHePacycwmxZL2
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 116 nm

Medium: water

Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. OcjILnAm57cJG6ZNAKc5BPL1uUIWW
  2. hzWfF3Rw2mAUc3zeF2WMuYDmbRUaJfWqhWczbwK55Jv6coUe2RarY4xbKsHXBfHysJZyhK
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 107.2 nm

Medium: water

Support: none

References

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