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5-fluorouracil encapsulated chitosan/TPP nanoparticles

Based on

7 Articles
2016 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

TPP-initiated chitosan nanoparticles

chitosan-TPP nanoparticles
Type Nano Material
Formula
Role carriers
2

5-fluoro-2,4(1H,3H)pyrimidinedione

5-Fluorouracil 5-fluorouracil fluorouracil Adrucil® Efudex® adrucil efudex 5-FU 5-Fu 5FU
Type Single Compound
Formula CONHCONHCHCF
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
atomic force microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
293T human embryonic kidney (HEK 293) cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
Product

5-fluorouracil encapsulated chitosan/TPP nanoparticles

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Product

5-fluorouracil encapsulated chitosan/TPP nanoparticles

Hydrodynamic diameter: ~ 200 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • 5-fluoro-2,4(1H,3H)pyrimidinedione
  • poly(ethylene glycol)-b-poly(N-(2-(4,6-diamino-1,3,5-triazin-2-ylamino)ethyl) acrylamide)
  1. 7eRFegDscqZgb3FRmRnTi7hUAECnNzyNF1
  2. sJ2SgjSD3AhU1CDNuwoasEbBB04
Product

5-fluorouracil encapsulated chitosan/TPP nanoparticles

Hydrodynamic diameter: ~ 80 - ~ 100 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • 5-fluoro-2,4(1H,3H)pyrimidinedione
  • poly(acrylic acid)-g-(N-(2-(4,6-diamino-1,3,5-triazin-2-ylamino)ethyl)acrylamide)-b-(t-butyl acrylate)
  1. OMLAN2UAgIUuc5mb6
Product

5-fluorouracil encapsulated chitosan/TPP nanoparticles

Hydrodynamic diameter: ~ 100 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • 5-fluoro-2,4(1H,3H)pyrimidinedione
  • n-hexadecyl palmitate
  • taurocholic acid sodium salt
  1. B9E0Mt3lQquY9kHo
  2. g1GaN1SDX7rHLcmoWtgSl2O
  3. CvyZGRDVl2G1DG8xEB06BfsY7SzNrfX9
Product

5-fluorouracil encapsulated chitosan/TPP nanoparticles

Size: 177 - 201 nm

Medium/Support: none

References

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