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gemcitabine-loaded PLGA nanoparticles

Based on

1 Articles
2013 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role carriers
2

(4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)

2',2'-difluoro-2'-deoxycytidine 2'-deoxy-2',2'-difluorocytidine 2',2'-difluorodeoxycytidine gemcitabine gemzar dFdC gem GEM Gem
Type Single Compound
Formula C9H11F2N3O4
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug entrapment efficiency

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
scanning electron microscopy

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(lactic-co-glycolic acid)
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  1. 0a6xmTCvCW94zv
  2. I8B
  3. FDnXY
  4. MyCl2zQ33N
Product

gemcitabine-loaded PLGA nanoparticles

Diameter: 385 - 399 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(lactic-co-glycolic acid)
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  1. zzQYgeWinDVYRO
  2. sT2
  3. 8yDTF
  4. QMsSaic7rW
Product

gemcitabine-loaded PLGA nanoparticles

Diameter: 248.4 - 261.4 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(lactic-co-glycolic acid)
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  1. jRcyqu4WDWKjSx
  2. 4v3
  3. gx4Gk
  4. qtty1EvZrr
Product

gemcitabine-loaded PLGA nanoparticles

Diameter: 235.5 - 250.5 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • poly(lactic-co-glycolic acid)
  1. 1iT1cne0xLed22
  2. nLR
  3. 48DM7
  4. nyamJ4l3R6
Product

gemcitabine-loaded PLGA nanoparticles

Diameter: 197.1 - 216.1 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • poly(lactic-co-glycolic acid)
  1. wfIMqvOYQ7a2bw
  2. Hbw
  3. N2DD7
  4. uhZ6Awseeq
Product

gemcitabine-loaded PLGA nanoparticles

Diameter: 194.5 - 213.5 nm

Medium/Support: none

References

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