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Her2-PLI/XIAP-siRNA polyplexes

Based on

1 Articles
2014 Most recent source

Composition

1

copolymer of poly(ethylene glycol) and poly-(L-lysine) grafting polyethylenimine

mPEG45-b-PLL42-g-(ss-lPEI15)10 mPEGn-b-PLLm-g-(ss-lPEIp)q mPEG-b-PLL-g-(ss-lPEI) PLI
Type Polymer
Formula
Role raw materials
2

Herceptin-functionalized PEG

Her2-PEG-COOH
Type Complex Compound
Formula
Role graft
3

ribonucleic acid

scrambled siRNA SCR
Type Biomolecule
Formula
Role loaded material

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Biological effects

Biological system Test details Nanomaterial Variant Source
nude mouse BALB/c bearing subcutaneous xenografts of Skov-3 tumor

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • Herceptin-functionalized PEG
  1. rT13hLoV
  2. 2paXJK3oIgYAYVN2N80nBbsbFslSpWKmuL92ovOUVWpUl5I3psvAB73vFMgwKu6ivku3NXUNNblMmXwp0d2JPsn4wwwB1JEKx4
Product

Her2-PLI/XIAP-siRNA polyplexes

Size: not specified

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • Herceptin-functionalized PEG
  1. o6v4BzHC
  2. HyObyWkWMxeYcqQbaaqmIGskysbKoJh2CGnazwjcg5QhzYPzvXbZweiSFAoeUpDkMRG8YatcgxNL3k7LBoB6F9XZzdXU3Nlqr0
Product

Her2-PLI/XIAP-siRNA polyplexes

Size: not specified

Medium/Support: none

References

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