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cyclic diguanylate monophosphate loaded capsid like hollow poly(DL-lactide-co-glycolide) polymeric nanoparticles

Based on

1 Articles
2019 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

PLGA nanoparticles

Type Nano Material
Formula
Role carriers
2

cyclic diguanylate monophosphate

Type Single Compound
Formula C20H24N10O14P2
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source

Details in source

Details in source

Details in source

Details in source

No matching record found

Biological effects

Biological system Test details Nanomaterial Variant Source

upregulation of CD80 genes

reduction in systemic reactogenicity, subcutaneous

C57BL/6 mouse

triggering host immune response, subcutaneous

decrease in survival rate of mouse, subcutaneous

human DPP4-transgenic mouse challenged with middle east respiratory syndrome coronavirus

no protection against middle east respiratory syndrome coronavirus, subcutaneous

cellular uptake

murine dendritic cell like JAWS II cells

dendritic cell maturation

No matching record found

Preparation

No matching record found

Method 1

Starting materials
  • cyclic diguanylate monophosphate
dissoluttion
1
  1. phosphate buffer pH 7
emulsification
2
  • poly(DL-lactide-co-glycolide)
  1. ice
  2. ultrasonic probe sonicator
  3. 40% amplitude
3
  1. phosphate buffer pH 7
  2. ultrasonic probe sonicator
  3. 30% amplitude
4
  1. pouring
  2. water
  3. 40 °C
  4. stirring
Product

cyclic diguanylate monophosphate loaded capsid like hollow poly(DL-lactide-co-glycolide) polymeric nanoparticles

References

Journal articles

Leon Chien‐Wei Lin; Chen‐Yu Huang; Bing‐Yu Yao; Jung‐Chen Lin; Anurodh Agrawal; Abdullah Algaissi; Bi‐Hung Peng; Yu‐Han Liu; Ping‐Han Huang; Rong‐Huay Juang; Yuan‐Chih Chang; Chien‐Te Tseng; Hui‐Wen Chen; Che‐Ming Jack Hu (2019)
Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus

Adv. Funct. Mater., vol. 29, issue 28, pp 1807616 - 1807616


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