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PLGA nanoparticles

Based on

13 Articles
2020 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

Type Polymer
Formula
Role raw materials

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source

Details in source

Details in source

Size: not specified

Medium/Support: none

View data for this variant only

Details in source

Size: not specified

Medium/Support: none

View data for this variant only

Details in source

Details in source

No matching record found

Applications

Area Application Nanomaterial Variant Source

treatment of lysosome dysfunctional diseases by restoring lysosomal function and autophagic flux in pancreatic β-cells

Size: not specified

Medium/Support: none

View data for this variant only

No matching record found

Characterization

Method Nanomaterial Variant Source

Hydrodynamic size: ~125 nm

Medium/Support: none

View data for this variant only

Size: not specified

Medium/Support: none

View data for this variant only

No matching record found

Biological effects

Biological system Test details Nanomaterial Variant Source

IFN-γ expression in tumor site, intravenous

Size: not specified

Medium/Support: none

View data for this variant only

no attachment to the tumor vasculature, intravenous

no induction of dendritic cell maturation

Size: not specified

Medium/Support: none

View data for this variant only

no inhibition of tumor growth, intravenous

no cell targeting

no significant inhibition of cell proliferation

Size: not specified

Medium/Support: none

View data for this variant only

no cell targeting

accumulation of autophagosomes in presence of palmitate

Size: not specified

Medium/Support: none

View data for this variant only

INS1 cells

cellular uptake

Size: not specified

Medium/Support: none

View data for this variant only

INS1 cells

increase in cathepsin L enzyme activity

Size: not specified

Medium/Support: none

View data for this variant only

INS1 cells

co-localization with lysosomes

Size: not specified

Medium/Support: none

View data for this variant only

INS1 cells

lysosomal pH restoration

Size: not specified

Medium/Support: none

View data for this variant only

INS1 cells

decrease in cell viability

Size: not specified

Medium/Support: none

View data for this variant only

INS1 cells

reduction in average lysosomal size

Size: not specified

Medium/Support: none

View data for this variant only

dysfunctional lysosomal acidification

Size: not specified

Medium/Support: none

View data for this variant only

lipotoxic INS1 cells

increase in insulin secretion

Size: not specified

Medium/Support: none

View data for this variant only

lipotoxic INS1 cells

no alteration of insulin content

Size: not specified

Medium/Support: none

View data for this variant only

lipotoxic INS1 cells

no restoration of glucose-stimulated insulin secretion

Size: not specified

Medium/Support: none

View data for this variant only

brain targeting efficiency, intravenous

Size: not specified

Medium/Support: none

View data for this variant only

male C57BL/6 mouse after MCAO surgery

accumulation in penumbra region, intravenous

Size: not specified

Medium/Support: none

View data for this variant only

biocompatible

Size: not specified

Medium/Support: none

View data for this variant only

MCF-7 cells

moderate cellular uptake

Size: not specified

Medium/Support: none

View data for this variant only

biodistribution, intravenous

Size: 409.5 nm

Medium/Support: none

View data for this variant only

non-cytotoxic at concentration up to 2000 μg/mL

Size: not specified

Medium/Support: none

View data for this variant only

No matching record found

Preparation

No matching record found

Method 1

Type: Physical formation
Starting materials
  • poly(lactic-co-glycolic acid)
drop-wise addition
1
  1. acetone
  2. water
evaporation
2
  1. vacuum aspirator
ultrafiltration
3
Product

PLGA nanoparticles

Method 2

Type: Physical formation
dispersion
1
Product

PLGA nanoparticles

Method 3

Type: Physical formation
Starting materials
  • poly(lactic-co-glycolic) acid
1
  1. dropwise addition
  2. 2.5% polyvinyl alcohol
  3. vortex
  4. ultrasonication
2
  1. 0.3% polyvinyl alcohol
  2. stirring
  3. 540 rpm
  4. overnight
  5. 4 °C
centrifugation
3
  1. 18000 rpm
  2. 20 min
4
  1. water
  2. 2 times washing
Product

PLGA nanoparticles

Size: not specified

Medium/Support: none

View data for this variant only

Method 4

Type: Chemical synthesis
Starting materials
  • poly(lactic-co-glycolic acid)
dissolution
1
  1. acetone
dropwise addition
2
  1. poly(vinyl alcohol) aqueous solution
  2. vigorous stirring
Product

PLGA nanoparticles

Method 5

Type: Physical formation
dispersion
1
Product

PLGA nanoparticles

References

Journal articles

Shuya Li; Qin Wang; Yanqiong Shen; Muhammad Hassan; Jizhou Shen; Wei Jiang; Yitan Su; Jing Chen; Li Bai; Wenchao Zhou; Yucai Wang (2020)
Pseudoneutrophil Cytokine Sponges Disrupt Myeloid Expansion and Tumor Trafficking to Improve Cancer Immunotherapy

Nano Lett., vol. 20, issue 1, pp 242 - 251

Jialiu Zeng; Orian S. Shirihai; Mark W. Grinstaff (2019)
Degradable Nanoparticles Restore Lysosomal pH and Autophagic Flux in Lipotoxic Pancreatic Beta Cells

Adv. Healthcare Mater., vol. 8, issue 12, pp 1801511 - 1801511

Leon Chien‐Wei Lin; Chen‐Yu Huang; Bing‐Yu Yao; Jung‐Chen Lin; Anurodh Agrawal; Abdullah Algaissi; Bi‐Hung Peng; Yu‐Han Liu; Ping‐Han Huang; Rong‐Huay Juang; Yuan‐Chih Chang; Chien‐Te Tseng; Hui‐Wen Chen; Che‐Ming Jack Hu (2019)
Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus

Adv. Funct. Mater., vol. 29, issue 28, pp 1807616 - 1807616

Xun Gong; Minkyung Park; Dorsa Parviz; Kevin S. Silmore; Pavlo Gordiichuk; Tedrick Thomas Salim Lew; Michael S. Strano (2019)
Single‐Particle Tracking for Understanding Polydisperse Nanoparticle Dispersions

Small, vol. 15, issue 37, pp 1901468 - 1901468

Junning Ma; Shenqi Zhang; Jun Liu; Fuyao Liu; Fenyi Du; Miao Li; Ann T. Chen; Youmei Bao; Hee Won Suh; Jonathan Avery; Gang Deng; Yu Zhou; Peng Wu; Kevin Sheth; Haijun Wang; Jiangbing Zhou (2019)
Targeted Drug Delivery to Stroke via Chemotactic Recruitment of Nanoparticles Coated with Membrane of Engineered Neural Stem Cells

Small, vol. 15, issue 35, pp 1902011 - 1902011

Arunkumar Pitchaimani; Tuyen Duong Thanh Nguyen; Ramesh Marasini; Achini Eliyapura; Tahmineh Azizi; Majid Jaberi-Douraki; Santosh Aryal (2019)
Biomimetic Natural Killer Membrane Camouflaged Polymeric Nanoparticle for Targeted Bioimaging

Adv. Funct. Mater., vol. 29, issue 4, pp 1806817 - 1806817

Ki Young Choi; Santiago Correa; Jouha Min; Jiahe Li; Sweta Roy; Kristiana H. Laccetti; Erik Dreaden; Stephanie Kong; Roun Heo; Young Hoon Roh; Edward C. Lawson; Peter A. Palmer; Paula T. Hammond (2019)
Binary Targeting of siRNA to Hematologic Cancer Cells In Vivo Using Layer‐by‐Layer Nanoparticles

Adv. Funct. Mater., vol. 29, issue 20, pp 1900018 - 1900018

Shulan Han; Wenjie Wang; Shengfang Wang; Shuo Wang; Ruijun Ju; Zihao Pan; Tingyuan Yang; Guifeng Zhang; Huimei Wang; Lianyan Wang (2019)
Multifunctional biomimetic nanoparticles loading baicalin for polarizing tumor-associated macrophages

Nanoscale, vol. 11, issue 42, pp 20206 - 20220

Yixuan Tang; Shuang Wu; Jiaqi Lin; Liting Cheng; Jing Zhou; Jing Xie; Kexin Huang; Xiaoyou Wang; Yang Yu; Zhangbao Chen; Guojian Liao; Chong Li (2018)
Nanoparticles Targeted against Cryptococcal Pneumonia by Interactions between Chitosan and Its Peptide Ligand

Nano Lett., vol. 18, issue 10, pp 6207 - 6213

Rong Yang; Jun Xu; Ligeng Xu; Xiaoqi Sun; Qian Chen; Yuhuan Zhao; Rui Peng; Zhuang Liu (2018)
Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination

ACS Nano, vol. 12, issue 6, pp 5121 - 5129

Jacob W. Myerson; Bruce Braender; Olivia Mcpherson; Patrick M. Glassman; Raisa Y. Kiseleva; Vladimir V. Shuvaev; Oscar Marcos-Contreras; Martha E. Grady; Hyun-Su Lee; Colin F. Greineder; Radu V. Stan; Russell J. Composto; David M. Eckmann; Vladimir R. Muzykantov (2018)
Flexible Nanoparticles Reach Sterically Obscured Endothelial Targets Inaccessible to Rigid Nanoparticles

Adv. Mater., vol. 30, issue 32, pp 1802373 - 1802373

Chunming Tang; Cong Wang; Ying Zhang; Lingjing Xue; Yanyi Li; Caoyun Ju; Can Zhang (2019)
Recognition, Intervention, and Monitoring of Neutrophils in Acute Ischemic Stroke

Nano Lett., vol. 19, issue 7, pp 4470 - 4477

Jianfeng Ji; Fei Ma; Hongbo Zhang; Fengyong Liu; Jian He; Wanlin Li; Tingting Xie; Danni Zhong; Tingting Zhang; Mei Tian; Hong Zhang; Hélder A. Santos; Min Zhou (2018)
Light-Activatable Assembled Nanoparticles to Improve Tumor Penetration and Eradicate Metastasis in Triple Negative Breast Cancer

Adv. Funct. Mater., vol. 28, issue 33, pp 1801738 - 1801738


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