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siRNA, PTX-loaded DSPE-PEG2000/DPPC/cholesterol/DOTAP nanoliposomes

Based on

1 Articles
2017 Most recent source

Composition

1

Hepes buffer saline

HBS
Type Complex Compound
Formula
Role core
2

1,2-dipalmitoyl-sn-glycero-phosphatidylcholine:N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium

DPPC:DOTAP
Type Complex Compound
Formula
Role layer
3

DPPC:DSPE-PEG2000:cholesterol

Type Complex Compound
Formula
Role layer
4

siRNA

Type Biomolecule
Formula
Role loaded material
5

Paclitaxel

Plaxicel Abraxane Paxene Taxol PCL PAC PTX PX
Type Single Compound
Formula C47H51NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female BALB/c nude mouse bearing human cervical cancer (HeLa) xenograft

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium
  • 1,2-dipalmitoyl-sn-glycero-phosphatidylcholine
  1. eZTx3cxwSyNzdtLELzScJeajg
Product

siRNA, PTX-loaded DSPE-PEG2000/DPPC/cholesterol/DOTAP nanoliposomes

Hydrodynamic diameter: 226 - 276 nm

Size: 196 - 214 nm

Medium/Support: none

References

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