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folic acid-functionalized monomolecular nucleic acid/lipid particles

Based on

1 Articles
2017 Most recent source

Composition

1

[5'-Cy3-d(CCAACAGTAAAAGGAATATCC)-3']*[5'-d(GGATATTCCTTTTACTGTTGG)-3']

Type Biomolecule
Formula
Role core
2

DOTAP/DOPE

Type Complex Compound
Formula
Role layer
3

DOPC/DSPE-PEG(2000)/DSPE-PEG(2000)-FolA

Type Complex Compound
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
fluorescence correlation spectroscopy

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Biological effects

Preparation

Method 1

Type: Physical formation
Source:
Product

folic acid-functionalized monomolecular nucleic acid/lipid particles

Size: not specified

Medium: 60 % serum/PBS

Support: none

Method 2

Type: Physical formation
Source:
Product

folic acid-functionalized monomolecular nucleic acid/lipid particles

Size: not specified

Medium: 40 % serum/PBS

Support: none

Method 3

Type: Physical formation
Source:
Product

folic acid-functionalized monomolecular nucleic acid/lipid particles

Size: not specified

Medium: 80 % serum/PBS

Support: none

Method 4

Type: Physical formation
Source:
Product

folic acid-functionalized monomolecular nucleic acid/lipid particles

Size: not specified

Medium: 90 % plasma/PBS

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium salt
  • (9Z)-9-Octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
See all (5)
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  2. P4Sj6sQAdJ69c
Product

folic acid-functionalized monomolecular nucleic acid/lipid particles

Hydrodynamic radius: 19.2 nm

Medium: water

Support: none

References

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