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doxorubicin-loaded mesoporous silica nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

1

mesoporous silica nanoparticles

MCM-41 MSN
Type Nano Material
Formula
Role core
2

(3-aminopropyl)-triethoxysilane moiety

(3-aminopropyl)trimethoxysilane moiety (3-aminopropyl)triethoxysilane moiety γ-aminopropyltriethoxy silane moiety 3-aminopropyltrimethoxysilane moiety 3-aminopropyltriethoxysilane moiety γ-aminopropyltriethoxysilane moiety (3-aminopropyl)trioxysilane moiety (3-aminopropyl)silanetrioxy group 3-aminopropylsilanetrioxy group 3-aminopropylsiloxy fragment 3-aminopropyl silane moiety 3-aminopropylsilane moiety γ-APTES moiety 3-APTS moiety APTES moiety APTMS moiety AMPS moiety APTS moiety APS moiety
Type Single Compound
Formula -C3H8NO3Si-
Role layer
3

azo-alkyne

Type Single Compound
Formula C17H12ClN3O2
Role layer
4

mono-(6-azido-6-desoxy)-β-cyclodextrin

mono-6-azido-6-deoxy-β-cyclodextrin mono-6-azido-cyclodextrin N3-β-CD β-CD-N3
Type Single Compound
Formula C42H69N3O34
Role layer
5

methoxy-PEG-NCO

Type Polymer
Formula
Role layer
6

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material

Properties

General physical and chemical properties

Property Value Source
drug release dependent on normoxic or hypoxic conditions

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Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
transmission electron microscopy

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Biological effects

Biological system Test details Source
A549/shCont cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • hexamethylene-1,6-di-isocyanate
  • methoxy poly(ethylene glycol)
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Product

doxorubicin-loaded mesoporous silica nanoparticles

References

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