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doxorubicin/p-gp siRNA-loaded polyethyleneimine-functionalized core-shell hierarchical mesoporous organosilica nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

1

mesoporous silica nanoparticles

MSN
Type Nano Material
Formula
Role core
2

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material
3

organosilica

Type Complex Compound
Formula
Role layer
4

(3-aminopropyl)trimethoxysilane moiety

(3-aminopropyl)trimethoxysilane moiety (3-aminopropyl)triethoxysilane moiety γ-aminopropyltriethoxy silane moiety 3-aminopropyltrimethoxysilane moiety γ-aminopropyltriethoxysilane moiety 3-aminopropyltriethoxysilane moiety (3-aminopropyl)trioxysilane moiety (3-aminopropyl)silanetrioxy group 3-aminopropylsilanetrioxy group 3-aminopropylsiloxy fragment 3-aminopropyl silane moiety 3-aminopropylsilane moiety γ-APTES moiety 3-APTS moiety APTES moiety APTMS moiety AMPS moiety APTS moiety APS moiety
Type Single Compound
Formula -C3H8NO3Si-
Role layer
5

butanedioic acid

succinic acid SuAcid SCA SuA SA
Type Single Compound
Formula C4H6O4
Role layer
6

PEI

Type Polymer
Formula
Role graft
7

P-gp siRNA

Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on glutathione (GSH) concentration

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
doxorubicin (DOX)-resistant MCF-7 cells (MCF-7/ADR)

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Preparation

Method 1

Type: Physical formation
Source:
  1. 5WGuG0
  2. kQUxI2
Product

doxorubicin/p-gp siRNA-loaded polyethyleneimine-functionalized core-shell hierarchical mesoporous organosilica nanoparticles

Size: not specified

Medium/Support: none

References

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