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cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Based on

2 Articles
2017 Most recent source

Composition

1

poly(acrylic acid)-b-poly(N-isopropylacrylamide)-b-poly(acrylic acid) triblock polymer

PAA150-b-PNIPAM200-b-PAA150
Type Polymer
Formula
Role carriers
2

cis-dichlorodiammineplatinum(II) moiety

cisplatin moiety CDDP moiety
Type Single Compound
Formula -H6N2Pt-
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
A549 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • cis-diammineplatinum(II) dichloride
  1. JcPQrkJxvV9zr2Dk
  2. JnAHG3O35MMMNN
  3. TrEb
  4. JO2hQSpt
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Size: ~ 500 nm

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • cis-diammineplatinum(II) dichloride
  1. KBSzzI4jWYyMevDy
  2. Qz4Chyc5UvVuLv
  3. hp2W
  4. wAlQ1tHc
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Hydrodynamic diameter: ~ 700 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Hydrodynamic diameter: ~ 700 nm

Medium: water

Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • cis-diammineplatinum(II) dichloride
  1. QKzpeIvgLlLiKoOGRTt9HCXLdQqkz6zLerGgwu5i
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Pore diameter: 2.61 nm

Medium/Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • cis-diammineplatinum(II) dichloride
  1. 05qqH9FzveiuoL2M
  2. jGb7GTZUAQRQNl
  3. lqT5
  4. q0vIJ05F
Product

cisplatin-directed coordination-crosslinking PAA-b-PNIPAM-b-PAA nanogel

Hydrodynamic diameter: ~ 1200 nm

Medium: water

Support: none

References

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