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TTD-loaded cRGD-functionalized DSPE-mPEG2000/DSPE-mPEG2000-Mal nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

1

1,2-Distearoyl-sn-glycero-3-phosphoethanol- amine-N-[maleimide(polyethylene glycol)-2000]/1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]

DSPE-PEG2000-Mal/DSPE-mPEG2000
Type Complex Compound
Formula
Role carriers
2

2-(2,6-bis((E)-4-(phenyl(4'-(1,2,2-triphenylvinyl)-[1,1'-biphenyl]-4-yl)amino)styryl)-4H-pyran-4-ylidene)malononitrile

TTD
Type Single Compound
Formula C100H70N4O
Role loaded material
3

thiolated cyclic (Arg-Gly-Asp-D-Phe-Lys(mpa)) peptide

c(RGDfK)-SH
Type Complex Compound
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female BALB/c nude mouse xenografted with human cholangiocarcinoma QBC939 cells

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Preparation

Method 1

Type: Physical formation
Source:
Product

TTD-loaded cRGD-functionalized DSPE-mPEG2000/DSPE-mPEG2000-Mal nanoparticles

Size: ~ 40 nm

Medium: water

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000]
  • thiolated cyclic (Arg-Gly-Asp-D-Phe-Lys(mpa)) peptide
  1. LYyeoVYXwQbqX
  2. pRnfnxYg
Product

TTD-loaded cRGD-functionalized DSPE-mPEG2000/DSPE-mPEG2000-Mal nanoparticles

Size: ~ 40 nm

Medium/Support: none

References

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