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Paclitaxel-loaded glutamate-modified polyoxyethylene stearate-decorated poly(lactic-co-glycolic acid) nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

Paclitaxel

Plaxicel Abraxane Paxene Taxol PAC PCL PTX PX
Type Single Compound
Formula C47H51NO14
Role loaded material
3

glutamate-modified polyoxyethylene stearate

Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female Balb/C mice bearing mouse mammary (4T1) tumor

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • glutamate-modified polyoxyethylene stearate
  • poly(lactic-co-glycolic acid)
  • Paclitaxel
  1. 1oFg2idLrRRZe8vz7hlYX8M7QwhShzGfVOqvA
Product

Paclitaxel-loaded glutamate-modified polyoxyethylene stearate-decorated poly(lactic-co-glycolic acid) nanoparticles

Hydrodynamic diameter: 141.9 - 161.5 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • glutamate-modified polyoxyethylene stearate
  • poly(lactic-co-glycolic acid)
  • Paclitaxel
  1. T8GI1F9EtgB2zRFg7aihiAkv3ywsnZPGRy6FK
Product

Paclitaxel-loaded glutamate-modified polyoxyethylene stearate-decorated poly(lactic-co-glycolic acid) nanoparticles

Hydrodynamic diameter: 158.6 - 181.0 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • glutamate-modified polyoxyethylene stearate
  • poly(lactic-co-glycolic acid)
  • Paclitaxel
  1. AWku28r3HC7gp7DeZsvixe0OeDeQzZDdJUo7T
Product

Paclitaxel-loaded glutamate-modified polyoxyethylene stearate-decorated poly(lactic-co-glycolic acid) nanoparticles

Hydrodynamic diameter: 160.8 - 178.4 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • glutamate-modified polyoxyethylene stearate
  • poly(lactic-co-glycolic acid)
  • Paclitaxel
  1. UUEQzJHn8iGJZgOKKulPeS7EM5Mcj2By37vfc
Product

Paclitaxel-loaded glutamate-modified polyoxyethylene stearate-decorated poly(lactic-co-glycolic acid) nanoparticles

Hydrodynamic diameter: 152.4 - 170.4 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • glutamate-modified polyoxyethylene stearate
  • poly(lactic-co-glycolic acid)
  • Paclitaxel
  1. LpdXWeYJ8Tq8DlXUG47u1GjmGKvV0qcUsSMnC
Product

Paclitaxel-loaded glutamate-modified polyoxyethylene stearate-decorated poly(lactic-co-glycolic acid) nanoparticles

Hydrodynamic diameter: 158.1 - 172.5 nm

Medium/Support: none

References

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