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225Ac-DOTA-loaded liposomes

Based on

1 Articles
2017 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

citrate buffer

Type Complex Compound
Formula
Role core
2

lipid mixture

Type Complex Compound
Formula
Role layer
3

DOTA-225Ac-chelate

Type Single Compound
Formula C16H28(225)AcN4O8
Role loaded material
4

L-(+)-ascorbic acid

L-ascorbic acid ascorbic acid ascorib acid Vitamin C vitamin C L-AA AA VC AC Vc
Type Single Compound
Formula C6H8O6
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
radioactivity retention in serum dependent on pH

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
HER2-negative MCF-7 cell spheroid

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,2-dihenarachidoyl-sn-glycero-3-phosphocholine
  • 1,2-distearoyl-sn-glycero-3-phosphate sodium salt
  • cholesterol
See all (5)
Product

225Ac-DOTA-loaded liposomes

Hydrodynamic diameter: 98 - 130 nm

Medium/Support: none

References

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