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vorinostat/bortezomib-loaded zein nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

zein nanoparticles

ZNP
Type Nano Material
Formula
Role carriers
2

pyrazylcarbonyl-Phe-Leuboronate

bortezomib Bortezomib Velcade PS-341 BTZ
Type Single Compound
Formula C19H25BN4O4
Role loaded material
3

N-Hydroxy-N`-phenyloctanediamide

suberanilohydroxamic acid vorinostat ZolinzaTM SAHA
Type Single Compound
Formula C14H20N2O3
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
atomic force microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
nude BALB/c mouse bearing prostate cancer PC3 cell xenograft

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • N-Hydroxy-N`-phenyloctanediamide
  • pyrazylcarbonyl-Phe-Leuboronate
  • zein
  1. C0hJW
  2. GabxYVw
Product

vorinostat/bortezomib-loaded zein nanoparticles

Hydrodynamic diameter: ~ 150 nm

Medium: phosphate buffer solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • N-Hydroxy-N`-phenyloctanediamide
  • pyrazylcarbonyl-Phe-Leuboronate
  • zein
  1. CdKzE
  2. w9XCFG3
Product

vorinostat/bortezomib-loaded zein nanoparticles

Size: ~ 160 nm

Medium/Support: none

References

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