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cisplatin prodrug/docetaxel-loaded poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

1

poly(lactic acid-co-glycolic acid)-b-poly(ethylene glycol)

PLGA-PEG
Type Polymer
Formula
Role carriers
2

C16H36Cl2N2O4Pt

Type Single Compound
Formula C16H36Cl2N2O4Pt
Role loaded material
3

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female athymic nude mouse bearing lung cancer 344SQ tumor xenograft

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • C16H36Cl2N2O4Pt
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic acid-co-glycolic acid)-b-poly(ethylene glycol)
  1. 1GPRynVSIPjZDMemZiZQv
  2. N6vQRnB7b32YvXJBMaS7
Product

cisplatin prodrug/docetaxel-loaded poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles

Hydrodynamic diameter: ~ 62 nm

Medium: phosphate buffer solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • C16H36Cl2N2O4Pt
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic acid-co-glycolic acid)-b-poly(ethylene glycol)
  1. YZWUeQFp8xmgdT3XsTybV
  2. PQ4qbaQm44zoQOISaA2X
Product

cisplatin prodrug/docetaxel-loaded poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles

Diameter: ~ 25 - ~ 35 nm

Hydrodynamic diameter: ~ 67 nm

Medium: phosphate buffer solution

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • C16H36Cl2N2O4Pt
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic acid-co-glycolic acid)-b-poly(ethylene glycol)
  1. E7cg7XP0IfZdBPqVDn0fx
  2. XlfT4vhYTBQSYK3IQ5P4
Product

cisplatin prodrug/docetaxel-loaded poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles

Size: not specified

Medium: phosphate buffer solution

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • C16H36Cl2N2O4Pt
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic acid-co-glycolic acid)-b-poly(ethylene glycol)
  1. fbn6KBgzO9eDpdpZ68OFz
  2. Y6ygSpYad7udht4Whjef
Product

cisplatin prodrug/docetaxel-loaded poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles

Hydrodynamic diameter: ~ 60 nm

Medium: phosphate buffer solution

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • C16H36Cl2N2O4Pt
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic acid-co-glycolic acid)-b-poly(ethylene glycol)
  1. KRtGjohOuzmRBA73RDduW
  2. YuoI8aqJGf6Vqa5W04Bb
Product

cisplatin prodrug/docetaxel-loaded poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles

Hydrodynamic diameter: ~ 64 nm

Medium: phosphate buffer solution

Support: none

References

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