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cisplatin prodrug/docetaxel-loaded poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

1

poly(lactic acid-co-glycolic acid)-b-poly(ethylene glycol)

PLGA-PEG
Type Polymer
Formula
Role carriers
2

C16H36Cl2N2O4Pt

Type Single Compound
Formula C16H36Cl2N2O4Pt
Role loaded material
3

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

Applications

Area Application Source
drug delivery

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Characterization

Method Source
dynamic light scattering

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Biological effects

Biological system Test details Source
female athymic nude mouse bearing lung cancer 344SQ tumor xenograft

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • C16H36Cl2N2O4Pt
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic acid-co-glycolic acid)-b-poly(ethylene glycol)
  1. KxdhU7a6feVDvMaCTQEk8
  2. U5efIhkLFCNrEubTPy5W
Product

cisplatin prodrug/docetaxel-loaded poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles

Method 2

Type: Physical formation
Source:
Starting materials
  • C16H36Cl2N2O4Pt
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic acid-co-glycolic acid)-b-poly(ethylene glycol)
  1. kEUyTeTWk2sRlr6I8QzGu
  2. uxY6YSQv0y42ixgiJfZ5
Product

cisplatin prodrug/docetaxel-loaded poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles

Method 3

Type: Physical formation
Source:
Starting materials
  • C16H36Cl2N2O4Pt
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic acid-co-glycolic acid)-b-poly(ethylene glycol)
  1. aE61JTSxklHdKuoQWqv0f
  2. asHKCNIYShN5oBwujge6
Product

cisplatin prodrug/docetaxel-loaded poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles

References

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