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human coagulation factor IX R338L mRNA-encapsulated lipid enabled and unlocked nucleic acid modified RNA nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

lipid composition

Type Complex Compound
Formula
Role carriers
2

human Factor IX protein R338L messenger mRNA

hFIX mRNA R338L
Type Biomolecule
Formula
Role loaded material

Properties

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
coagulation factor IX-deficient (FIX<sup>-/-</sup>) hemophilic mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • di((Z)-non-2-en-1-yl) 8,8'-((((2-(dimethylamino)ethyl)thio)carbonyl)azanediyl)dioctanoate
  • human Factor IX protein R338L messenger mRNA
  • cholesterol
See all (5)
  1. D38JQDWAs156y4lQ1jWrywIWjkJTtAlvxbVUCNWJi
  2. BUCpda
Product

human coagulation factor IX R338L mRNA-encapsulated lipid enabled and unlocked nucleic acid modified RNA nanoparticles

Size: not specified

Medium/Support: none

References

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