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streptokinase-loaded ligand-decorated cholesterol/maleimide-terminated polyethylene glycol-conjugated distearyl phosphatidyl ethanolamine/distearyl phosphatidyl choline nanovesicles

Based on

1 Articles
2017 Most recent source

Composition

1

phosphate buffer solution

PBS
Type Complex Compound
Formula
Role core
2

maleimide-terminated polyethylene glycol-conjugated distearyl phosphatidyl ethanolamine/distearyl phosphatidyl choline

DSPC/DSPE-PEG2000-mal
Type Complex Compound
Formula
Role layer
3

RGD-peptide

Type Biomolecule
Formula
Role layer
4

EWVDV-peptide

Type Biomolecule
Formula
Role layer
5

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
6

streptokinase

SK
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on phospholipase A2 presence

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
cryo-electron microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
C57Bl/6 mouse with ferric chloride-induced carotid artery thrombosis model

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • maleimide-terminated polyethylene glycol-conjugated distearyl phosphatidyl ethanolamine
  • RGD-peptide
  • EWVDV-peptide
Product

streptokinase-loaded ligand-decorated cholesterol/maleimide-terminated polyethylene glycol-conjugated distearyl phosphatidyl ethanolamine/distearyl phosphatidyl choline nanovesicles

Diameter: 150 - 170 nm

Medium/Support: none

References

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