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siRNA-loaded lipid nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

1

HEPES-citrate buffer

Type Complex Compound
Formula
Role core
2

1,2-di-O-octadecenyl-3-trimethylammoniumpropane/1,2-dioleyloxy-N,N-dimethyl-3-aminopropane/L-α-phosphatidylcholine

DOTMA/DODMA/L-α-phosphatidylcholine
Type Complex Compound
Formula
Role layer
3

methyl-poly(ethylene glycol)-cholesterol

mPEG-Chol
Type Polymer
Formula
Role loaded material
4

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
5

5'-Cy3-siRNA

Type Biomolecule
Formula
Role loaded material

Properties

Applications

Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
human liver hepatocellular HepG2 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • methyl-poly(ethylene glycol)-cholesterol
  • 1,2-dioleyloxy-N,N-dimethyl-3-aminopropane
  • cholesterol
See all (5)
  1. xVarJXbMpk1x9jH690KiYq
Product

siRNA-loaded lipid nanoparticles

Size: not specified

Medium/Support: none

References

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