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disulfide-bridged and doxorubicin-embedded degradable silica nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

disulfide-bridged silica

Type Complex Compound
Formula
Role core
2

doxorubicin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material
3

hydroxyl group

hydroxy group hydroxyl hydroxy
Type Single Compound
Formula -OH
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on dithiothreitol presence

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Applications

Characterization

Method Nanomaterial Variant Source
atomic force microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
nude mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • 3-[3-(triethoxysilyl)propyl]-1-(2-{[2-({[3-(triethoxysilyl)propyl]carbamoyl}amino)ethyl]disulfanyl}ethyl)urea
  • doxorubicin
  • silicic acid tetraethyl ester
  1. GufQFJs
Product

disulfide-bridged and doxorubicin-embedded degradable silica nanoparticles

Diameter: ~ 98 - ~ 108 nm

Pore diameter: 2 - 22 nm

Medium/Support: none

References

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