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siMDR1/9R-Dox-loaded APTEDB-PEG2000-DSPE/POPC/POPG liposomes

Based on

1 Articles
2017 Most recent source

Composition

1

HEPES-buffered glucose

HBG
Type Complex Compound
Formula
Role core
2

N-maleimide-polyethylene glycol(2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine (ammonium salt)/polyethylene glycol(2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine (ammonium salt)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)

mal-PEG2000-DSPE/PEG2000-DSPE/POPC/POPG
Type Complex Compound
Formula
Role layer
3

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
4

EDB domain of fibronectin

APTEDB
Type Biomolecule
Formula
Role layer
5

nona-arginine peptide

9R
Type Biomolecule
Formula
Role loaded material
6

siMDR1

Type Biomolecule
Formula
Role loaded material
7

doxorubicin hydrogen chloride

adriblastin hydrochloride doxorubicin hydrochloride adriamycin hydrochloride doxorubicin hydrochoride adriblastin HCl salt adriamycin HCl salt DOX hydrochloride DXR hydrochloride doxorubicin HCl DOX*HCl DOX-HCl DOX·HCl DXR HCl DXR*HCl Dox HCl Dox*HCl DOXS
Type Single Compound
Formula C27H29NO11*HCl
Role loaded material

Properties

General physical and chemical properties

Property Value Source
Zeta potential

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Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
dynamic light scattering

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Biological effects

Biological system Test details Source
Balb/c nude mouse xenografted with dox-resistant human breast adenocarcinoma MCF-7/ADR cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • EDB domain of fibronectin/N-maleimide-polyethylene glycol(2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine
  • 1-palmitoyl-2- oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)
  • polyethylene glycol(2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine (ammonium salt)
See all (5)
  1. RteLS0tH9ouCRRfqlRM
Product

siMDR1/9R-Dox-loaded APTEDB-PEG2000-DSPE/POPC/POPG liposomes

References

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