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docetaxel-loaded maleimide-modified poly(lactide-co-glycolide)-polyethylene glycol nanoparticles

Based on

2 Articles
2017 Most recent source

Composition

1

maleimide-modified poly(lactide-co-glycolide)-polyethylene glycol nanoparticles

PLGA-PEG NP
Type Nano Material
Formula
Role carriers
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on fetal bovine serum presence

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
male athymic NCr nude mouse xenografted with human prostate cancer PC3M cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • maleimide-poly(lactide-co-glycolide)-polyethylene glycol
  • poly(lactide-co-glycolide)-polyethylene glycol
  1. yEWiQUbadLhHd
Product

docetaxel-loaded maleimide-modified poly(lactide-co-glycolide)-polyethylene glycol nanoparticles

Size: not specified

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  1. mbLeQL
  2. zQX
Product

docetaxel-loaded maleimide-modified poly(lactide-co-glycolide)-polyethylene glycol nanoparticles

Size: not specified

Medium/Support: none

Method 3

Type: Physical formation
Source:
Product

docetaxel-loaded maleimide-modified poly(lactide-co-glycolide)-polyethylene glycol nanoparticles

Size: ~ 200 nm

Medium: water

Support: none

References

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