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CpG-loaded HEL-conjugated calcium phosphate nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

1

calcium orthophosphate

β-tricalcium phosphate tricalcium phosphate calcium phosphate β-TCP CaPh CaP TCP CP
Type Single Compound
Formula Ca3(PO4)2
Role core
2

poly(iminoethylene)

polyethyleneimine polyaziridine PEI
Type Polymer
Formula
Role layer
3

silicon dioxide

silicic oxide silica
Type Single Compound
Formula SiO2
Role layer
4

(3-mercaptopropyl)trimethoxysilyloxy moiety

(3-mercaptopropyl)-triethoxysilane moiety (3-mercaptopropyl)silanetriyltrioxy group (3-mercaptopropyl)trimethoxysilane moiety 3-(trimethoxysilyl)-1-propanethiol moiety 3-mercaptopropyl(trimethoxy)silane moiety (3-mercaptopropyl)triethoxysilane moiety 3-(triethoxysilyl)-1-propanethiol moiety 3-mercaptopropyl trimethoxysilane moiety 3-mercaptopropyltrimethoxy silane moiety 3-mercaptopropyltrimethoxysilane moiety γ-mercaptopropyl triethoxysilane moiety 3-mercaptopropyltriethoxysilane moiety (3-mercaptopropyl)trioxysilane moiety (3-mercaptopropyl)silanetrioxy group (3-mercaptopropyl)silyloxy moiety 3-mercaptopropyl siloxane moiety (3-mercaptopropyl)siloxane unit 3-mercaptopropylsilyloxy moiety 3-mercaptopropyl silane moiety 3-mercaptopropysilyloxy moiety 3-mercaptopropylsilane moiety mercaptopropyltriethoxysilane 3-mercaptopropylsiloxy group 3-MPTES moiety 3-MPTS moiety MPTES moiety MPTMS moiety STMOS moiety MPTS moiety MPS moiety
Type Single Compound
Formula -C3H7O3SSi-
Role layer
5

4-(N-maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester moiety

carbonyl-1,4-cyclohexanediylmethylene-2,5-dioxopyrrolidine-1,3-diyl unit 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid moiety sulfo-SMCC linker moiety sulfo-SMCC moiety sulfo-SMCC linker sulfo-SMCC unit SMCC moiety
Type Single Compound
Formula -C12H15NO3-
Role graft
6

hen egg lysozyme

HEL
Type Biomolecule
Formula
Role graft
7

bacterial cytosine phosphodiester guanine oligomer

CpG
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
C3H/HeOuJ mouse

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Preparation

Method 1

Type: Physical formation
Source:
Product

CpG-loaded HEL-conjugated calcium phosphate nanoparticles

Diameter: 90 nm

Hydrodynamic diameter: 274 nm

Medium: water

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • poly(iminoethylene)
  • calcium lactate
  • diammonium hydrogen orthophosphate
  1. pK40n
Product

CpG-loaded HEL-conjugated calcium phosphate nanoparticles

Diameter: 90 nm

Medium/Support: none

References

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