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PEGylated poly-L-lysine/poly-L-arginine/poly(styrene sulfonate)17-coated poly(styrene sulfonate)70-stabilized paclitaxel nanocrystals

Based on

1 Articles
2017 Most recent source

Composition

1

poly-L-arginine/poly(styrene sulfonate)17-coated poly(styrene sulfonate)70-stabilized paclitaxel nanocrystals

PLR/PSS17-coated PSS70-stabilized PTX NC (NC/PSS70)-(PLR/PSS17)
Type Nano Material
Formula
Role core
2

poly-L-lysine

PLL
Type Biomolecule
Formula
Role layer
3

mPEG succinimidyl propionate moiety

mPEG-SPA moiety
Type Polymer
Formula
Role graft

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female NMRI-nu mouse xenografted with human colon adenocarcinoma HT-29 cells

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Preparation

Method 1

Type: Physical formation
Source:
Product

PEGylated poly-L-lysine/poly-L-arginine/poly(styrene sulfonate)17-coated poly(styrene sulfonate)70-stabilized paclitaxel nanocrystals

Diameter: ~ 270 nm

Medium: DMEM/10% FBS

Support: none

Method 2

Type: Physical formation
Source:
Product

PEGylated poly-L-lysine/poly-L-arginine/poly(styrene sulfonate)17-coated poly(styrene sulfonate)70-stabilized paclitaxel nanocrystals

Diameter: ~ 220 nm

Medium: phosphate buffer solution

Support: none

Method 3

Type: Physical formation
Source:
Product

PEGylated poly-L-lysine/poly-L-arginine/poly(styrene sulfonate)17-coated poly(styrene sulfonate)70-stabilized paclitaxel nanocrystals

Diameter: ~ 250 nm

Medium: DMEM/10% FBS

Support: none

Method 4

Type: Physical formation
Source:
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  3. rTd7eAl
Product

PEGylated poly-L-lysine/poly-L-arginine/poly(styrene sulfonate)17-coated poly(styrene sulfonate)70-stabilized paclitaxel nanocrystals

Size: not specified

Medium/Support: none

Method 5

Type: Physical formation
Source:
Product

PEGylated poly-L-lysine/poly-L-arginine/poly(styrene sulfonate)17-coated poly(styrene sulfonate)70-stabilized paclitaxel nanocrystals

Diameter: ~ 230 nm

Medium: phosphate buffer solution

Support: none

References

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