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docetaxel-loaded maleimide-modified poly(lactide-co-glycolide)-polyethylene glycol nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

1

maleimide-modified poly(lactide-co-glycolide)-polyethylene glycol nanoparticles

PLGA-PEG NP
Type Nano Material
Formula
Role carriers
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Source
drug release dependent on fetal bovine serum presence

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Applications

Characterization

Biological effects

Biological system Test details Source
male athymic NCr nude mouse xenografted with human prostate cancer PC3M cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • maleimide-poly(lactide-co-glycolide)-polyethylene glycol
  • poly(lactide-co-glycolide)-polyethylene glycol
  1. OlXoXrKaPmoxv
Product

docetaxel-loaded maleimide-modified poly(lactide-co-glycolide)-polyethylene glycol nanoparticles

References

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