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mRNA/N1,N3,N5-tris(3-(didodecylamino) propyl)benzene-1,3,5-tricarboxamide/cholesterol/1,2-dimyristoyl-sn-glycerol, methoxypolyethylene glycol/(diethylenetriaminepentaacetic acid)-bis(stearylamide)-gadolinium salt nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

1

(diethylenetriaminepentaacetic acid)-bis(stearylamide)-gadolinium salt

diethylenetriaminepentaacetic acid)-bis(stearylamide) gadolinium salt diethylenetriaminepentaacetic acid bis(stearylamide) gadolinium salt gadolinium diethylenetriaminepentaacetate-di(stearylamide) Gd-DTPA-di(stearylamide) Gd-DTPA-BSA Gd-DTPA-DSA
Type Single Compound
Formula C50H94GdN5O8
Role carriers
2

N1,N3,N5-tris(3-(didodecylamino) propyl)benzene-1,3,5-tricarboxamide

TT3
Type Single Compound
Formula C90H174N6O3
Role loaded material
3

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
4

1,2-dimyristoyl-sn-glycerol, methoxypolyethylene glycol

DMG-PEG2000
Type Polymer
Formula
Role loaded material
5

messenger RNA

mRNA
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
T1 relaxation time

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Applications

Area Application Nanomaterial Variant Source
diagnostics

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Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
human hepatoma (Hep3B) cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • cholesterol
  • N1,N3,N5-tris(3-(didodecylamino) propyl)benzene-1,3,5-tricarboxamide
  • (diethylenetriaminepentaacetic acid)-bis(stearylamide)-gadolinium salt
See all (4)
  1. ULhyBny8xRsUhplw
Product

mRNA/N1,N3,N5-tris(3-(didodecylamino) propyl)benzene-1,3,5-tricarboxamide/cholesterol/1,2-dimyristoyl-sn-glycerol, methoxypolyethylene glycol/(diethylenetriaminepentaacetic acid)-bis(stearylamide)-gadolinium salt nanoparticles

Size: 173 - 175 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Product

mRNA/N1,N3,N5-tris(3-(didodecylamino) propyl)benzene-1,3,5-tricarboxamide/cholesterol/1,2-dimyristoyl-sn-glycerol, methoxypolyethylene glycol/(diethylenetriaminepentaacetic acid)-bis(stearylamide)-gadolinium salt nanoparticles

Size: ~ 100 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Product

mRNA/N1,N3,N5-tris(3-(didodecylamino) propyl)benzene-1,3,5-tricarboxamide/cholesterol/1,2-dimyristoyl-sn-glycerol, methoxypolyethylene glycol/(diethylenetriaminepentaacetic acid)-bis(stearylamide)-gadolinium salt nanoparticles

Size: 173 - 175 nm

Medium: water

Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • cholesterol
  • N1,N3,N5-tris(3-(didodecylamino) propyl)benzene-1,3,5-tricarboxamide
  • 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
See all (4)
  1. P4bNbdHoihza840N
Product

mRNA/N1,N3,N5-tris(3-(didodecylamino) propyl)benzene-1,3,5-tricarboxamide/cholesterol/1,2-dimyristoyl-sn-glycerol, methoxypolyethylene glycol/(diethylenetriaminepentaacetic acid)-bis(stearylamide)-gadolinium salt nanoparticles

Size: ~ 100 nm

Medium/Support: none

References

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