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PEGylated docetaxel linked with D-α-tocopherol via disulfide bound nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

docetaxel linked with D-α-tocopherol via disulfide bound

DTX-S-S-VE
Type Single Compound
Formula C76H105NO18S2
Role core
2

1,2-distearoyl-sn-glycero-3-phosphatidylethanolamine-poly(ethylene glycol)

DSPE-PEG2000
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female BALB/c mouse xenografted with human lung adenocarcinoma A549 cells

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Preparation

Method 1

Type: Physical formation
Source:
Product

PEGylated docetaxel linked with D-α-tocopherol via disulfide bound nanoparticles

Diameter: ~ 180 nm

Medium: phosphate buffer solution

Support: none

Method 2

Type: Physical formation
Source:
Product

PEGylated docetaxel linked with D-α-tocopherol via disulfide bound nanoparticles

Diameter: 172.4 - 175.2 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Product

PEGylated docetaxel linked with D-α-tocopherol via disulfide bound nanoparticles

Diameter: ~ 180 nm

Medium: bovine serum albumin solution

Support: none

Method 4

Type: Physical formation
Source:
Product

PEGylated docetaxel linked with D-α-tocopherol via disulfide bound nanoparticles

Diameter: ~ 220 nm

Medium: bovine serum albumin solution

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
Product

PEGylated docetaxel linked with D-α-tocopherol via disulfide bound nanoparticles

Diameter: ~ 180 nm

Medium: Roswell Park Memorial Institute medium 1640

Support: none

References

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