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siPRK2-loaded 1,2-epoxidodecane-modified spermine/1,2-distearoyl-sn-glycero-3-phosphocholine/cholesterol/C16-PEG2000-caramine/α-galactosyl ceramide liposomes

Based on

1 Articles
2016 Most recent source

Composition

1

Vacuous

Type
Formula
Role core
2

1,2-epoxidodecane-modified spermine/1,2-distearoyl-sn-glycero-3-phosphocholine/cholesterol/C16-PEG2000-caramine/α-galactosyl ceramide

C12-SPM/DSPC/cholesterol/C16-PEG2000-caramine/α-galactosyl ceramide
Type Complex Compound
Formula
Role layer
3

endogenous host kinase-small interfering RNA

siPRK2
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human hepatic Huh-7 cells with genotype 1b HCV subgenomic replicons

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Preparation

Method 1

Type: Physical formation
Source:
Product

siPRK2-loaded 1,2-epoxidodecane-modified spermine/1,2-distearoyl-sn-glycero-3-phosphocholine/cholesterol/C16-PEG2000-caramine/α-galactosyl ceramide liposomes

Diameter: ~ 120 nm

Medium: DMEM/10% FBS

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • α-galactosyl ceramide
  • N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)2000]}
  • cholesterol
See all (5)
  1. iCW2bOK2Z6bkdqaZar3EwL3ZV
Product

siPRK2-loaded 1,2-epoxidodecane-modified spermine/1,2-distearoyl-sn-glycero-3-phosphocholine/cholesterol/C16-PEG2000-caramine/α-galactosyl ceramide liposomes

Diameter: ~ 110 - ~ 120 nm

Medium/Support: none

References

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