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PEGylated docetaxel linked with D-α-tocopherol via disulfide bound nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

docetaxel linked with D-α-tocopherol via disulfide bound

DTX-S-S-VE
Type Single Compound
Formula C76H105NO18S2
Role core
2

1,2-distearoyl-sn-glycero-3-phosphatidylethanolamine-poly(ethylene glycol)

DSPE-PEG2000
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Source
drug release dependent on glutathione concentration

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Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
transmission electron microscopy

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Biological effects

Biological system Test details Source
female BALB/c mouse xenografted with human lung adenocarcinoma A549 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • docetaxel linked with D-α-tocopherol via disulfide bound
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Product

PEGylated docetaxel linked with D-α-tocopherol via disulfide bound nanoparticles

References

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