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9-bromo-N-(2,5,8,11,15,18,21,24-octaoxapentacosan-13-yl)perylene-3,4-dicarboxy monoimide-loaded poly(L-lactide)-block-peptide-block-poly(L-lactide) nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

polylactide-block-(Ac)SGFG-LALGPG-GFGS(NH2)-block-polylactide

PLLA-b-(Ac)SGFG-LALGPG-GFGS(NH2)-b-PLLA PLA-b-(Ac)SGFG-LALGPG-GFGS(NH2)-b-PLA
Type Polymer
Formula
Role core
2

9-bromo-N-(2,5,8,11,15,18,21,24-octaoxapentacosan-13-yl)perylene-3,4-dicarboxy monoimide

PMI
Type Single Compound
Formula C39H44BrNO10
Role loaded material
3

poly(isoprene)-b-polyethylene glycol

poly(isoprene)-b-polyethylene oxide PI-b-PEO PI-b-PEG
Type Polymer
Formula
Role layer
4

Lutensol® AP 20

Lutensol AP 20
Type Complex Compound
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on matrix metalloproteinase-2 (MMP-2) presence

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Applications

Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
myogenic cell line C2C12

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Preparation

Method 1

Type: Physical formation
Source:
Product

9-bromo-N-(2,5,8,11,15,18,21,24-octaoxapentacosan-13-yl)perylene-3,4-dicarboxy monoimide-loaded poly(L-lactide)-block-peptide-block-poly(L-lactide) nanoparticles

Hydrodynamic diameter: 101 - 113 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Product

9-bromo-N-(2,5,8,11,15,18,21,24-octaoxapentacosan-13-yl)perylene-3,4-dicarboxy monoimide-loaded poly(L-lactide)-block-peptide-block-poly(L-lactide) nanoparticles

Hydrodynamic diameter: 75 - 121 nm

Medium: water

Support: none

References

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