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siRNA-absorbed doxorubicin/paclitaxel-encapsulated poly(2-(2-methoxyethoxy)ethyl methacrylate-co-oligo (ethylene glycol) methacrylate)-co-2-(dimethylamino)ethyl methacrylate-b-poly(lactic-co-glycolic acid) nanoparticles

Based on

1 Articles
2017 Most recent source

Composition

1

water

Type Single Compound
Formula H2O
Role core
2

poly(2-(2-methoxyethoxy)ethyl methacrylate-co-oligo (ethylene glycol) methacrylate)-co-2-(dimethylamino)ethyl methacrylate-b-poly(lactic-co-glycolic acid)

P(MEO2MA-co-OEGMA-co-DMAEMA)-b-PLGA
Type Polymer
Formula
Role layer
3

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material
4

Paclitaxel

Abraxane Plaxicel Paxene Taxol PAC PCL PTX PX
Type Single Compound
Formula C47H51NO14
Role loaded material
5

small interfering RNA

siRNA
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Source
drug release dependent on type of drug

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Applications

Characterization

Method Source
transmission electron microscopy

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Biological effects

Biological system Test details Source
MDA-MB-231 breast cancer cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(2-(2-methoxyethoxy)ethyl methacrylate-co-oligo (ethylene glycol) methacrylate)-co-2-(dimethylamino)ethyl methacrylate-b-poly(lactic-co-glycolic acid)
  1. jOXoIAjh2NTd81l5dO
Product

siRNA-absorbed doxorubicin/paclitaxel-encapsulated poly(2-(2-methoxyethoxy)ethyl methacrylate-co-oligo (ethylene glycol) methacrylate)-co-2-(dimethylamino)ethyl methacrylate-b-poly(lactic-co-glycolic acid) nanoparticles

References

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