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erlotinib/cyclopamine-encapsulating irinotecan/riboflavin-containing PEG-based polymer nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

erlotinib/cyclopamine mixture

ET/CP
Type Complex Compound
Formula
Role core
2

irinotecan-modified polyethyleneglycol-based biphenyl-4-carboxylic acid derivative

BCA-C6-PEG-S-Ir polymer
Type Polymer
Formula
Role layer
3

riboflavin-modified polyethyleneglycol-based biphenyl-4-carboxylic acid derivative

BCA-C6-PEG-R polymer
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Source
erlotinib-cyclopamine cumulative release dependent on rat liver microsome enzymes treatment presence

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Applications

Characterization

Method Source
scanning electron microscopy

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Biological effects

Biological system Test details Source
female BALB/c nude mice bearing with MCF-7 xenograft tumor

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • erlotinib
  • irinotecan-modified polyethyleneglycol-based biphenyl-4-carboxylic acid derivative
  • cyclopamine
See all (4)
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Product

erlotinib/cyclopamine-encapsulating irinotecan/riboflavin-containing PEG-based polymer nanoparticles

References

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