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10-hydroxycamptothecin-loaded phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone)-hydrazone bond-doxorubicin micelles

Based on

1 Articles
2016 Most recent source

Composition

1

phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone)-hydrazone bond-doxorubicin

PBA-PEG-ss-PCL-hyd-DOX
Type Polymer
Formula
Role raw materials
2

10-hydroxycamptothecin

hydroxycamptothecin 10-HCPT HCPT CPT
Type Single Compound
Formula C20H16N2O5
Role loaded material

Properties

General physical and chemical properties

Property Value Source
doxorubicin release dependent on glutathione concentration

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Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
transmission electron microscopy

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Biological effects

Biological system Test details Source
MCF-7/ADR DOX-resistant human breast cancer cells

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MCF-7/ADR tumor-bearing nude mouse

Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone)-hydrazone bond-doxorubicin
  • 10-hydroxycamptothecin
  1. d4Gehqkg1s1B0yx
  2. IMUQK
  3. OtMNSPjOfM24iuDel5
Product

10-hydroxycamptothecin-loaded phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone)-hydrazone bond-doxorubicin micelles

Method 2

Type: Physical formation
Source:
Starting materials
  • phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone)-hydrazone bond-doxorubicin
  • 10-hydroxycamptothecin
  1. QJhnA8GAlEl0Pbx
  2. B6jjj
  3. 3ZrIPCz60ij1fsCfg6
Product

10-hydroxycamptothecin-loaded phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone)-hydrazone bond-doxorubicin micelles

Method 3

Type: Physical formation
Source:
Product

10-hydroxycamptothecin-loaded phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone)-hydrazone bond-doxorubicin micelles

Method 4

Type: Physical formation
Source:
Starting materials
  • phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone)-hydrazone bond-doxorubicin
  • 10-hydroxycamptothecin
  1. bhiqeSkC9NEmFAZ
  2. dAU8r
  3. qIVzKGQhmxtiIE9ByT
Product

10-hydroxycamptothecin-loaded phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone)-hydrazone bond-doxorubicin micelles

References

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