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10-hydroxycamptothecin-loaded phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone) micelles

Based on

1 Articles
2016 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone)

PBA-PEG-ss-PCL
Type Polymer
Formula
Role raw materials
2

10-hydroxycamptothecin

hydroxycamptothecin 10-HCPT HCPT CPT
Type Single Compound
Formula C20H16N2O5
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
transmission electron microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
MCF-7/ADR DOX-resistant human breast cancer cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 10-hydroxycamptothecin
  • phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone)
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  2. zT70F
  3. lsddKYli7f0Kx1NJZL
Product

10-hydroxycamptothecin-loaded phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone) micelles

Hydrodynamic diameter: 117 - 137 nm

Medium: phosphate buffer solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 10-hydroxycamptothecin
  • phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone)
  1. Ii2MGSWhUrvqhMO
  2. xPAIh
  3. DKCcnXC7GQftCYKfWa
Product

10-hydroxycamptothecin-loaded phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone) micelles

Size: not specified

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • 10-hydroxycamptothecin
  • phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone)
  1. rCev12UWFYpNAhl
  2. skhIC
  3. 1LSJ9yApgGrYqyduzt
Product

10-hydroxycamptothecin-loaded phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone) micelles

Hydrodynamic diameter: 127 - 147 nm

Medium: phosphate buffer solution

Support: none

Method 4

Type: Physical formation
Source:
Product

10-hydroxycamptothecin-loaded phenylboronic acid-polyethylene glycol-disulfide bond-poly(ε-caprolactone) micelles

Hydrodynamic diameter: 126 - 134 nm

Medium: phosphate buffer solution

Support: none

References

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