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non-nucleoside reverse transcriptase inhibitor/hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

stearic acid-acylated hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer

stearic acid-acylated methoxypoly(ethylene glycol)5000-graft-N-ε-poly-L-lysine hydrophobic core protected graft copolymer MPEG5-PLL21-stearoyl HC-PGC
Type Biomolecule
Formula
Role raw materials
2

1-[2-[4-chloro-2-(3,5-dimethylbenzoyl)phenoxy]ethyl]-1,5,6,7-tetrahydro-2H-cyclopenta[d]pyrimidine-2,4(3H)-dione

benzophenone-uracyl scaffold-derived Z107 DPU Z107 Z107
Type Single Compound
Formula C24H23ClN2O4
Role raw materials

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
MAGI-CCR5 cells with HIV-1 virus

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • stearic acid-acylated hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer
  • 1-[2-[4-chloro-2-(3,5-dimethylbenzoyl)phenoxy]ethyl]-1,5,6,7-tetrahydro-2H-cyclopenta[d]pyrimidine-2,4(3H)-dione
  1. 7MKzgpnK5rj0TSPlxynlKAsB
Product

non-nucleoside reverse transcriptase inhibitor/hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer nanoparticles

Number-corrected hydrodynamic diameter: 256 - 450 nm

Z-average hydrodynamic diameter: 310.0 nm

Medium: HEPES buffered saline

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • oleic acid-acylated hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer
  • 1-[2-[4-chloro-2-(3,5-dimethylbenzoyl)phenoxy]ethyl]-1,5,6,7-tetrahydro-2H-cyclopenta[d]pyrimidine-2,4(3H)-dione
  1. 3OoVGtftX5IpuYicBwowHs94
Product

non-nucleoside reverse transcriptase inhibitor/hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer nanoparticles

Diameter: 200 - 300 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • stearic acid-acylated hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer
  • 1-[2-[4-chloro-2-(3,5-dimethylbenzoyl)phenoxy]ethyl]-1,5,6,7-tetrahydro-2H-cyclopenta[d]pyrimidine-2,4(3H)-dione
  1. whDH8QcYwu4sqb882GlUJLUH
Product

non-nucleoside reverse transcriptase inhibitor/hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer nanoparticles

Size: not specified

Medium/Support: none

Method 4

Type: Physical formation
Source:
Product

non-nucleoside reverse transcriptase inhibitor/hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer nanoparticles

Number-corrected hydrodynamic diameter: 154 - 298 nm

Z-average hydrodynamic diameter: 272.0 nm

Medium: HEPES buffered saline

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • stearic acid-acylated hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer
  • 1-[2-[4-chloro-2-(3,5-dimethylbenzoyl)phenoxy]ethyl]-1,5,6,7-tetrahydro-2H-cyclopenta[d]pyrimidine-2,4(3H)-dione
  1. 6qOgylbPG64rRQBBrEpnveMG
Product

non-nucleoside reverse transcriptase inhibitor/hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer nanoparticles

Number-corrected hydrodynamic diameter: 93 - 217 nm

Z-average hydrodynamic diameter: 370.0 nm

Medium: HEPES buffered saline

Support: none

References

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